Central effect of mammalian oxyntomodulin on food intake in non-fasted and fasted chicks

Authors

  • A. Ghazanfari Moghaddam Department of Biology, College of Sciences, University of Tehran, Tehran, Iran
  • H. Jonaidi Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran
  • H. Sepehri Department of Biology, College of Sciences, University of Tehran, Tehran, Iran
  • M. Abbasnejad Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran
  • M. M. Yaghoobi Department of Biotechnology, International Center for Science and High Technology and Environmental Sciences, Mahan, Iran
Abstract:

Oxyntomodulin (OXM), a proglucagon-derived peptide, is a well known anorexigenic peptide found inthe gut and brain of mammals. The present study was carried out to investigate the central effect of OXM onfood intake in non-fasted and fasted Ross broiler chicks. At four weeks of age, a guide cannula wasstereotaxically implanted into the right lateral ventricle of each bird. Two experiments were conducted onfree-feeding (non-fasted) and 6-h fasted broilers. In each experiment, eight birds were used in a replicated 4 × 4 Latin square design. The birds were given an intracerebroventricular (ICV) injection of different doses of mammalian OXM. Intracerebroventricular injection of OXM at doses of 1.5, 3 and 6 nmol significantly(P

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Journal title

volume 11  issue 1

pages  51- 55

publication date 2010-03-20

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